JAAM-2 DIC Algorithm

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Diagnostic Criteria for the Diagnosis of DIC: The Japanese Association for Acute Medicine [JAAM] JAAM-2 DIC Algorithm for Sepsis

Introduction

The JAAM-2 DIC scoring algorithm is based on the JAAM DIC algorithm but excludes the Systemic Inflammatory Response Syndrome [SIRS] data, Fibrinogen levels and has additional modifications.

The JAAM-2 DIC Algorithm:

Select Criteria:

Platelet Count
	<80 x 10⁹/L or >50% decrease within 24 hrs	3 Points
	≥80 - <120 x 10⁹/L or >30% decrease within 24 hrs	1 Point
FDPs [µg/mL] or D-dimer
	≥25 µg/mL	3 Points
	≥10 - <25 µg/mL	1 Point
Prothrombin Time ratio [PT]
	≥1.2	1 Point

Score
[Max score 7]

JAAM-2 DIC Score
≥3	Supports a diagnosis of DIC

For additional information on the JAAM-2 DIC Algorithm - see references.

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Comments

NOTE: Whilst we have done our utmost to ensure the accuracy of the data in this section, users should access the original publications. This will also allow you to see how the algorithm was created, the population studied and any limitations to the study.

All information contained in this section of Practical-Haemostasis.com is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease.

The user of Practical-Haemostasis.com, assumes sole responsibility for any decisions made or actions taken based on the information contained herein.

LINKS & References

1. Iba T, Di Nisio M, et al. A Proposal of the Modification of Japanese Society on Thrombosis and Hemostasis (JSTH) Disseminated Intravascular Coagulation (DIC) Diagnostic Criteria for Sepsis-Associated DIC. Clin Appl Thromb Hemost. 2018; 24: 439-45.

2. ba T, Levy JH, Yamakawa K, et al. Proposal of a two-step process for the diagnosis of sepsis-induced disseminated intravascular coagulation. J Thromb Haemost. 2019;17(8):1265-8.

3. Umemura Y, Yamakawa K, Mori H, et al. Validity of Diagnosis of Disseminated Intravascular Coagulation Based on International Classification of Diseases Coding in a Claims Database. Thromb Haemost. 2025;125(8):757-65.

4. Yamakawa K, Okamoto K, Seki Y, et al. Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis. International journal of hematology. 2025;121(5):592-604.

5. Yamakawa K, Umemura Y, Mochizuki K, et al. Proposal and Validation of a Clinically Relevant Modification of the Japanese Association for Acute Medicine Disseminated Intravascular Coagulation Diagnostic Criteria for Sepsis. Thromb Haemost. 2024;124(11):1003-12.

6. Matsuoka T, Yamakawa K, Umemura Y, et al. The modified Japanese Association for Acute Medicine disseminated intravascular coagulation diagnostic criteria in sepsis is useful for an indicator of initiating treatment for disseminated intravascular coagulation. Thromb Res. 2025;253:109408.