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NOTE: Whilst we have done our utmost to ensure the accuracy of the data in this section, users should access the original publications.

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1.  The original WELLS score [1998], Wells employed a seven-component clinical prediction rule for PE.
   Score of >6: High risk for PE
   Score 2-6: Intermediate risk for PE
   Score <2: Low risk for PE

In 2000 the WELLS score for PE was revised to reduce the number of risk categories to two:
   Score ≤ 4: PE Unlikely
   Score >4:  PE Likely

2. The sensitivity of D-dimer tests varies and a highly sensitive D-dimer assay should be employed.

3. Current NICE guidelines recommend when using a point-of-care or laboratory D-dimer test, to consider the use of an age-adjusted D-dimer test threshold for people aged over 50.

1. Wells PS, Ginsberg JS, et al. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Annals of internal medicine. 1998; 129: 997-1005.

2. Wells PS, Anderson DR, et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer. Thromb Haemost. 2000; 83: 416-20.

3. Wells PS, Anderson DR, et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med. 2003; 349: 1227-35.

4. NICE Guidance for DVT & PE