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The French TMA score is based upon the national registry and was developed to allow the identification of acquired ADAMTS13 deficiency in the absence of an ADMTS13 assay being readily available. Three variables were identified and these form the TMA algorithm,
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NOTE: Whilst we have done our utmost to ensure the accuracy of the data in this section, users should access the original publications.
This will also allow you to see how the algorithm was created, the population studied and any limitations to the study.
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1. A score of 1 in any category had a positive predictive value of 85%, a negative predictive value of 93.3%, sensitivity of 98.8%, and specificity of 48.1% for severe ADAMTS13 deficiency [<5% normal activity].
1. Coppo P, Schwarzinger M, et al. Predictive features of severe acquired ADAMTS13 deficiency in idiopathic thrombotic microangiopathies: the French TMA reference center experience. PloS one. 2010; 5: e10208.
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Updated:
27-Sep-2022