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French Mortality in TTP Score [MITS]

Introduction:

The French Mortality in TTP Score [MITS] is a clinical prognostic algorithm for estimating mortality in hospitalised patients with TTP.

The MITS Score:


Select Criteria:

Platelet Transfusions
1 Point
Ischaemic Stroke
1 Point
Renal Failure [Acute/Chronic Renal Failure/Need for Haemodialysis
1 Point
Myocardial Infarction
1 Point
Age ≥60 Years
2 Points
CNS Bleed
3 Points
Arterial Thrombosis
3 Points

Score

[Max Score 12 points]

Interpretation:  In-hospital Mortality
0 0.72%
1 5.47%
2 8.33%
3 19.60%
4 26.67%
5 35.36%
6 60.00%
7-12 Too few patients to allow calculation of mortality



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Comments:

The MITS scoring system is based on a national database and was used to develop the MITS prognostic risk stratified score aimed at identifying hospitalised TTP patients at the highest probability of a fatal outcome and therefore who would potentially benefit from additional/more intensive treatments.

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Comments

NOTE: Whilst we have done our utmost to ensure the accuracy of the data in this section, users should access the original publications. This will also allow you to see how the algorithm was created, the population studied and any limitations to the study.

All information contained in this section of Practical-Haemostasis.com is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease.

The user of Practical-Haemostasis.com, assumes sole responsibility for any decisions made or actions taken based on the information contained herein.

1. Too few patients were available in the analysis to allow calculation of the mortality risk with a score of 7-12.

LINKS & References

1. Goel R, King KE, et al. Prognostic risk-stratified score for predicting mortality in hospitalized patients with thrombotic thrombocytopenic purpura: nationally representative data from 2007 to 2012. Transfusion. 2016; 56: 1451-8.

2. Benhamou Y, Assie C, et al. Development and validation of a predictive model for death in acquired severe ADAMTS13 deficiency-associated idiopathic thrombotic thrombocytopenic purpura: the French TMA Reference Center experience. Haematologica. 2012; 97: 1181-6.

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Updated:         27-Sep-2022