A Practical Guide to Laboratory Haemostasis


Genetics in Haemostasis


This section of is designed to introduce you to molecular genetics as it relates to the inherited bleeding disorders. It is not a primer on genetics - there are some excellent sites on the internet that will do that. The Web also contains a number of useful mutational databases and related to the genetics of the inherited bleeding disorders and we have included links to some of these.

Much of this is devoted to X-linked disorders but the principles are similar to autosomal disorders.

This part of the site is divided into 3 principal sections:

Pedigree and Bayesian Risk Analysis
Linkage Analysis
Mutational Analysis

A further section adresses the Factor V Leiden and the Prothrombin G20210A mutations.

Data Interpretation

Click HERE to go to the Data Interpretation Exercises.